Structural insights into control of cell growth by nutrient Biology Diagrams Pioneering work carried out over 60 years ago discovered that bacterial cell size is proportional to the growth rate set by nutrient availability. This relationship is traditionally referred to as the 'growth law'. Subsequent studies revealed the growth law to hold across all orders of life, a remar โฆ
Abstract. Adaptation to fluctuations in nutrient availability is a fact of life for single-celled organisms in the 'wild'. A decade ago our understanding of how bacteria adjust cell cycle parameters to accommodate changes in nutrient availability stemmed almost entirely from elegant physiological studies completed in the 1960s.
Metabolic Regulation of the Cell Cycle Biology Diagrams
Among the modulators of cell cycle progression are specific nutrients, which function as energy sources or regulate the production and/or function of proteins needed to advance cells through a replicative cycle. In this review, we focus on the roles of specific nutrients (vitamin A, vitamin D, iron, folic acid, vitamin B12, zinc, and glucose
In fact, these data argue that nutrient availability alters at least some aspects of cell cycle progression. Changing one nutrient at a time is an approach to determine how specific nutrients affect cell cycle control, while formulating media based on physiological metabolite levels will more generally reflect how cell cycle control differs in A) In a sizer model, cells actively measure a parameter directly related to cell size, such as volume, length, or surface area, and use that information to trigger division.B) In adder models, cells add a constant amount of material (blue) during each cell cycle, regardless of the cell's starting size. Over time, stochastic variations in cell size are mitigated. Pioneering work carried out over 60 years ago discovered that bacterial cell size is proportional to the growth rate set by nutrient availability. This relationship is traditionally referred to as the 'growth law'. Subsequent studies revealed the growth law to hold across all orders of life, a remarkable degree of conservation. However, recent work suggests the relationship between growth
The bidirectional relationship between metabolism and cell cycle ... Biology Diagrams
Adaptation to fluctuations in nutrient availability is a fact of life for single-celled organisms in the 'wild'. A decade ago our understanding of how bacteria adjust cell cycle parameters to However, the molecular wiring that connects nutrient availability, biosynthetic intermediates and energetic balance to the core cell cycle machinery remains incompletely understood. In this review, we explore the recent progress in this area with particular emphasis on how nutrient and energetic status is sensed within the cell to ultimately Together, these results suggest that T cell exhaustion and, more broadly, epigenomic remodelling are influenced by the source of nutrients such as acetyl-CoA. Original reference: Science 387
