Short Telomeres Flirt with Stem Cell Commitment Biology Diagrams The direct regulation of TR transcription by E2F1-Dp suggests a model in which telomere addition is synchronized with cell-cycle progression. This illustrates a robust coupling between the TR life cycle and host cell-cycle machinery, ensuring effective telomere maintenance and genomic stability throughout multiple rounds of cell divisions .
However, repair at telomeres was only observed in proliferating cells, such as BJ fibroblasts and HeLa cells. Interestingly, HeLa cells, which are faster dividing cells, display a faster repair kinetics compared to slower dividing fibroblasts, suggesting that proliferation rate is an important determinant of telomeric DSB repair (Mao et al., 2016).
Telomere function and regulation from mouse models to human ... Biology Diagrams
The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres. Cell Cycle 13, to DNA replication and repair and telomere maintenance. Mol. Biol. Cell 23,
Telomere maintenance requires the telomerase and a network of telomere-associated proteins, (TIF), telomere end-end fusion, and ultimately cell cycle arrest, senescence, and genome instability [13, 14]. In human, telomere dysfunction has been implicated in bone marrow failure syndromes, leukemia, and cancer development [9, 10, 15
Telomeres: history, health, and hallmarks of aging Biology Diagrams
The role of telomere attrition and damage in inducing permanent cell cycle arrest was further demonstrated using human fibroblasts overexpressing a mutant form of TRF2 ensures proper telomere maintenance in normal cells. At the same time, each of these features is vulnerable to mutations and dysregulation, leading to familial and sporadic Recently determined structures of the telomere maintenance protein complexes shelterin and CST shed new light on the regulation of telomere DNA replication and chromosome end-capping, and on how
