MYC signaling in inflammatory and cancerous Biology Diagrams The activation of STAT3 by the cytokine receptor gp130 is required for both the G1 to S cell cycle transition and antiapoptosis. We found that Pim-1 and Pim-2 are targets for the gp130-mediated STAT3 signal. Expression of a kinase-defective Pim-1 mutant attenuated gp130-mediated cell proliferation. Constitutive expression of Pim-1 together with c-myc, another STAT3 target, fully compensated
We will review here the role of MYC as cell-cycle brake releaser i.e., how MYC stimulates cell cycle mainly through the repression of cell-cycle inhibitors . Cell-cycle progression is regulated by serine/threonine protein kinases composed by a catalytic subunit or CDK (cyclin-dependent protein kinase), and a regulatory subunit, the cyclin [ 43
MYC Oncogene Contributions to Release of Cell Cycle Brakes Biology Diagrams
Effects of c-myc expression on cell cycle progression. K D Hanson. K D Hanson. 1 Department of Molecular Biophysics, Yale University School of Medicine, New Dean M., Sonenshein G. E. Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation. Cell. 1984 Feb;36(2):241-247. doi: 10.1016/0092-8674(84)90217
Enforced c-Myc expression promotes inappropriate cell cycle progression of growth factor deprived cells and triggers concomitant apoptosis. However, it is not clear what role dysregulation of the cell cycle plays in c-Myc-induced apoptosis. Ornithine decarboxylase (ODC) is a transcriptional target o โฆ
myc expression on cell cycle progression Biology Diagrams
An indirect proof of the role of Myc in cell cycle progression is the fact that Mxd proteins (Mxd1, Mxi1, Mxd3, Mxd4 and Mnt), which bind to Myc-binding sites and antagonize Myc transcriptional activity, inhibit cell proliferation (reviewed in [80], [81], [82]). Cell cycle arrest is also observed upon the enforced expression of MadMyc, a To gain a clearer understanding of the role of c-Myc in cellular proliferation, we have performed a comprehensive analysis of the components that regulate cell cycle progression. The largest defect observed in c-myc-/- cells is a 12-fold reduction in the activity of cyclin D1-Cdk4 and -Cdk6 complexes during the G0-to-S transition. The role of c-Myc in the cell cycle is further highlighted by the marked prolongation of the doubling time of cells in which both alleles of c-myc were eliminated by homologous Shichiri M, Follansbee M R, Sedivy J M. Effects of c-myc expression on cell cycle progression. Mol Cell Biol. 1994;14:5748-5755. doi: 10.1128/mcb.14.9.5748.
