Cell cycle control across the eukaryotic kingdom Trends in Cell Biology Biology Diagrams Cell division cycles and checkpoints are altered during both development and cancer. We have focused on a cell cycle variation that results in polyploid cells: the endocycle (Figure 1). Endocycling cells grow and periodically duplicate their DNA without dividing (G/S cycle), and ultimately become large, polyploid cells. Maintenance of genome stability depends on efficient, accurate repair of DNA damage. DNA double-strand breaks (DSBs) are among the most lethal types of DNA damage, with the potential to cause mutation, chromosomal rearrangement, and genomic instability that could contribute to cancer. CtIP coordinates DNA repair and cell cycle checkpoints
The cycle begins with the G1 phase, where the cell grows, synthesizes proteins, and accumulates energy reserves for DNA replication. Regulatory mechanisms assess whether conditions are favorable, ensuring sufficient nutrients and no external stressors threaten genomic stability.
The cell cycle revisited: DNA replication past S phase preserves genome ... Biology Diagrams
Telomeres and their associated proteins protect the ends of chromosomes to maintain genome stability. Telomeres undergo progressive shortening with each cell division in mammalian somatic cells without telomerase, resulting in genome instability. When telomeres reach a critically short length or are recognized as a damage signal, cells enter a state of senescence, followed by cell cycle arrest The two key events that execute these tasks in the course of the cell cycle are DNA replication in S phase and genome segregation during mitosis, respectively. Genome stability maintenance pathways have so far mainly been studied in interphase cells, but the question of the mechanisms by which cells are suppressing genome instability during To preserve genome integrity and proper cell-cycle progression, eukaryotic cells have developed checkpoint functions that are constantly monitoring DNA integrity and that serve to coordinate
Polyubiquitin-mediated degradation of proteins plays an essential role in various physiological processes including cell cycle progression, transcription and DNA replication and repair. Increasing evidence supports a vital role for the E3 ubiquitin ligase cullin-4, in conjunction with the substrate โฆ
Genome instability: a mechanistic view of its causes and ... Biology Diagrams
Maintaining genome integrity is essential to preserve cell survival and prevent malignant transformation. DNA replication and chromosome segregation are inherently challenging for genome stability, and the cell has evolved intricate mechanisms to regulate these two major cell cycle events in tight coordination, thus ensuring that a faithful copy of the genetic material is passed down to
